Ryan: [How should we answer] "What questions do you have about working at xyz"?

The questions you ask at the end of your interview should primarily serve you, and help you decide if the job is a good fit. Culture or work environment questions are good for that. Yes, if you do not ask a question, it could be interpreted negatively, but you should not worry about trying to impress your interviewer with a pithy question to make a strong impression; you have already done this or not!

Just don't say anything risky or inappropriate. I once had a candidate ask me to comment on a recent legal issue concerning my company. I guess she thought that she would win points for doing her homework, but I didn't take it that way.

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